Supporting Materials

BVBLUE®

BVBLUE® Control Kit

References:

Clinical Performance of BVBLUE:

  • Bradshaw, C.S. et al. 2005. Evaluation of point-of-care test, BVBLUE, and clinical and laboratory criteria for diagnosis of bacterial vaginosis. J. Clin. Microbiol. 43:1304.
  • Myziuk, L. et al. 2003. BVBLUE test for diagnosis of bacterial vaginosis. J. Clin. Microbiol. 41:1925.
  • McGregor, J.A. et al. 2003. Quantitative vaginal fluid sialidase (BVBLUE) correlates with Nugent’s Score vaginal gram stain testing in symptomatic women. Presented at Infectious Disease Society for Obstetrics and Gynecology (IDSOG). Hyannis, MA. USA.
  • McGregor, J.A. et al. 2002. Assessing vaginal fluid sialidases in women with bacterial vaginosis (BV). Presented at Infectious Disease Society for Obstetrics and Gynecology (IDSOG). Banff, Alberta, Canada.
  • McGregor, J.A. et al. 2002. Vaginal fluid concentration of sialidase (neurominidase) correlation with common vaginal conditions. Presented at Infectious Disease Society for Obstetrics and Gynecology (IDSOG). Banff, Alberta, Canada.
  • Johnson, S.C. et al. 2002. Clinical performance of the BVBLUE test for evaluation of vaginal fluid sialidase activity and its diagnostic value for evaluation of bacterial vaginosis.  Clin. Chem. 48:A191.
  • Myziuk, L. et al. 2002. Comparison of BVBLUE to standard methodology for diagnosing bacterial vaginosis. Presented at American Association for Microbiology (ASM). Salt Lake City, UT, USA.
  • McGregor, J.A. et al. 2000. Vaginal fluid sialidase enzyme activity in patients with positive BVBLUE test, candidiasis, trichomoniasis, and in healthy controls. Presented at Third International Meeting on Bacterial Vaginosis. Ystad, Sweden.
  • French, J.I. et al. 2000. Point of care diagnosis of bacterial vaginosis by analysis of BVBLUE, Amsel’s criteria, and gram’s stain. Presented at Third International Meeting on Bacterial Vaginosis. Ystad, Sweden.

Elevated sialidase activity in patients with Bacterial Vaginosis:

  • Cauci, S. et al. 2003. Determination of Immunoglobin A against Gardnerella vaginalis hemolysin, sialidase, and prolidase activities in vaginal fluid.  Implications for adverse pregnancy outcomes.  J. Clin. Microbiol. 41:435.
  • Cauci, s. et al. 2002. Correlation of local interleukin-8 with Immunoglobin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis.  J. Infect. Dis. 185:1614.
  • Smayevsky, J. et al. 2001. Vaginal microflora associated with bacterial vaginosis in nonpregnant women: reliability of sialidase detection. Infect. Dis. Obstet. Gynecol. 9:17.
  • Wiggins, R. et al. 2001. Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract. Sex. Transm. Infect. 77:402.
  • Cauci, S. et al. 1998. Immunoglobulin A response against Gardnerella vaginalis hemolysin and sialidase activity in bacterial vaginosis. Am. J. Obstet. Gynecol. 178:511.
  • McGregor, J.A. et al. 1994. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream. Am. J. Obstet. Gynecol. 170:1048.

Elevated sialidase activity in isolates of Gardnerella vaginalis, Bacteroides spp., Prevotella spp., and Mobiluncus spp.:

  • Briselden, A. et al. 1992. Sialidases (neuraminidases) in bacterial vaginosis and bacterial vaginosis-associated microflora. J. Clin. Microbiol. 30:663.
  • Moncla, B.J. et al. 1990. Sialidase (neuraminidase) activity among gram-negative anaerobic and capnophilic bacteria. J. Clin. Microbiol. 28:422.